Airway plaque presenting after alteration of immunosuppression in a pediatric patient remote from heart transplantation

Pediatr Transplant. 2017 Nov;21(7). doi: 10.1111/petr.13046. Epub 2017 Aug 24.

Abstract

Success after solid organ transplantation is dependent on the proper balance of immunosuppression to prevent rejection of the allograft while limiting the risk of developing infections and malignancy. We present a 9-year-old girl, remote from transplant, who presented with airway plaque after a change in immunosuppression to include the mTOR inhibitor sirolimus. Differential diagnosis included direct medication side effect, infection, and neoplasia.

Keywords: EBV; airway; heart transplant; immunosuppression; mTOR inhibitor; post-transplant lymphoproliferative disorder.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Epstein-Barr Virus Infections / diagnosis*
  • Epstein-Barr Virus Infections / immunology
  • Female
  • Graft Rejection / prevention & control
  • Heart Transplantation*
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / administration & dosage*
  • Immunosuppressive Agents / therapeutic use
  • Lymphoproliferative Disorders / diagnosis*
  • Lymphoproliferative Disorders / immunology
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / immunology
  • Sirolimus / administration & dosage*
  • Sirolimus / therapeutic use

Substances

  • Immunosuppressive Agents
  • Sirolimus