Intracavitary and Systemic Daptomycin for Successful Treatment of a Postpneumonectomy Intrathoracic Infection

Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01330-17. doi: 10.1128/AAC.01330-17. Print 2017 Nov.

Abstract

Treatment of an infected postpneumonectomy cavity is very difficult. We present a patient with an infection of a postpneumonectomy cavity by Staphylococcus epidermidis treated with local daptomycin for different dwell times, maintaining high antibiotic levels above the MIC. Clinical and microbiological cure were achieved successfully.

Keywords: Staphylococcus; daptomycin; intracavitary; postpneumonectomy cavity; treatment.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intravenous
  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / therapeutic use*
  • Daptomycin / administration & dosage
  • Daptomycin / pharmacokinetics
  • Daptomycin / therapeutic use*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Pneumonectomy / adverse effects*
  • Postoperative Complications / diagnostic imaging
  • Postoperative Complications / drug therapy
  • Postoperative Complications / microbiology*
  • Staphylococcal Infections / diagnostic imaging
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / etiology
  • Staphylococcus epidermidis / drug effects
  • Staphylococcus epidermidis / pathogenicity

Substances

  • Anti-Bacterial Agents
  • Daptomycin