Cytogenetic evidence for the clonal hematopoietic cell origin of alveolar macrophages in myelodysplastic syndrome-associated pulmonary alveolar proteinosis

Ann Hematol. 2017 Dec;96(12):2141-2143. doi: 10.1007/s00277-017-3118-3. Epub 2017 Aug 28.

Authors

Yuya Nagai¹, Chiyuki Kishimori², Miho Nakagawa², Ikkoh Yasuda³, Gen Honjo⁴, Hitoshi Ohno^{5

6}

Affiliations

¹ Department of Hematology, Tenri Hospital, 200 Mishima, Tenri, Nara, 632-8552, Japan.
² Tenri Institute of Medical Research, Tenri, Japan.
³ Department of Respiratory Medicine, Tenri Hospital, Tenri, Japan.
⁴ Department of Diagnostic Pathology, Tenri Hospital, Tenri, Japan.
⁵ Department of Hematology, Tenri Hospital, 200 Mishima, Tenri, Nara, 632-8552, Japan. [email protected].
⁶ Tenri Institute of Medical Research, Tenri, Japan. [email protected].

PMID: 28849334
DOI: 10.1007/s00277-017-3118-3

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Chromosomes, Human, Pair 1 / ultrastructure*
Clone Cells / pathology*
Fatal Outcome
Female
Hematopoietic Stem Cell Transplantation
Humans
In Situ Hybridization, Fluorescence
Macrophages, Alveolar / pathology*
Middle Aged
Mucin-1 / analysis
Myelodysplastic Syndromes / complications*
Myelodysplastic Syndromes / pathology
Pre-B-Cell Leukemia Transcription Factor 1 / genetics*
Pulmonary Alveolar Proteinosis / etiology*
Pulmonary Alveolar Proteinosis / pathology
Pulmonary Alveolar Proteinosis / therapy
Stomach Neoplasms / complications

Substances

MUC1 protein, human
Mucin-1
Pre-B-Cell Leukemia Transcription Factor 1
PBX1 protein, human