Diagnosis of congenital toxoplasmosis in a renal transplant recipient mother

J Gynecol Obstet Hum Reprod. 2017 Oct;46(8):661-663. doi: 10.1016/j.jogoh.2017.08.004. Epub 2017 Aug 26.

Abstract

We report the case of a first trimester toxoplasmosis infection in a renal transplant recipient. Real-time polymerase chain reaction in amniotic fluid at 18 weeks was negative for Toxoplasma gondii but at 26 weeks major fetal hydrocephalus was discovered leading to medical termination of pregnancy. Pathological examination confirmed lesions consistent with congenital toxoplasmosis. The herein case report, as well as data from the French reference centre for congenital Toxoplamosis (1835 cases in the past eight years), suggests that the strategy of management of pregnancy's first trimester Toxoplasmosis infection in patients treated by immunosuppressive therapy needs to be reconsidered.

Keywords: Congenital toxoplasmosis; PCR; Renal transplant.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amniotic Fluid / parasitology
  • DNA, Protozoan / genetics
  • Female
  • Humans
  • Kidney Transplantation
  • Pregnancy
  • Pregnancy Trimester, First
  • Prenatal Diagnosis
  • Real-Time Polymerase Chain Reaction
  • Toxoplasmosis, Congenital / diagnosis*
  • Transplant Recipients*

Substances

  • DNA, Protozoan