Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria

Tsin W Yeo; Salvatore M Florence; Ayam R Kalingonji; Youwei Chen; Donald L Granger; Nicholas M Anstey; Esther D Mwaikambo; J Brice Weinberg

doi:10.1093/ofid/ofx079

Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria

Open Forum Infect Dis. 2017 Apr 22;4(2):ofx079. doi: 10.1093/ofid/ofx079. eCollection 2017 Spring.

Authors

Tsin W Yeo^{1

2

3}, Salvatore M Florence⁴, Ayam R Kalingonji⁴, Youwei Chen⁵, Donald L Granger⁶, Nicholas M Anstey³, Esther D Mwaikambo⁴, J Brice Weinberg⁵

Affiliations

¹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
² Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore.
³ Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
⁴ Hubert Kairuki Memorial University, Dar es Salaam, Tanzania.
⁵ Duke University and V.A. Medical Centers, Durham, North Carolina; and.
⁶ University of Utah and V.A. Medical Centers, Salt Lake City.

Abstract

Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), not SM (P = .06), children had increased oxygen consumption compared with controls.

Keywords: Plasmodium falciparum; microvascular function; oxygen consumption; severe malaria..

Abstract

Grants and funding