A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity

Affiliations

• ¹ Institute of Applied Microbiology, RWTH, Aachen, Germany. [email protected].
• ² Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
• ³ Institute of Applied Microbiology, RWTH, Aachen, Germany.
• ⁴ Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands.
• ⁵ Department of Cardiovascular Sciences, Leuven University, Leuven, Belgium.
• ⁶ Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands.
• ⁷ InSphero AG, Schlieren, Switzerland.
• ⁸ Instituto de Investigación Sanitaria. Hospital Universitario La Fe, Valencia, Spain.
• ⁹ Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland.
• ¹⁰ Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK.
• ¹¹ Luxcel Biosciences Ltd, Cork, Ireland.
• ¹² European Molecular Biology Laboratory, Cambridge, UK.
• ¹³ Genedata AG, Basel, Switzerland.
• ¹⁴ Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.
• ¹⁵ Department of Imaging Sciences and BioMedical Engineering, King's College London, London, UK.
• ¹⁶ Microdiscovery GmbH, Berlin, Germany.
• ¹⁷ Optibrium Ltd, Cambridge, UK.