Biodistribution of Viscumin after Subcutaneous Injection to Mice and In Vitro Modeling of Endoplasmic Reticulum Stress

D V Maltseva; N A Krainova; N A Khaustova; S V Nikulin; S A Tonevitskaya; A A Poloznikov

doi:10.1007/s10517-017-3826-7

Biodistribution of Viscumin after Subcutaneous Injection to Mice and In Vitro Modeling of Endoplasmic Reticulum Stress

Bull Exp Biol Med. 2017 Aug;163(4):451-455. doi: 10.1007/s10517-017-3826-7. Epub 2017 Aug 29.

Authors

D V Maltseva¹, N A Krainova², N A Khaustova², S V Nikulin², S A Tonevitskaya², A A Poloznikov²

Affiliations

¹ BioClinicum Research Centre, Moscow, Russia. [email protected].
² BioClinicum Research Centre, Moscow, Russia.

PMID: 28853091
DOI: 10.1007/s10517-017-3826-7

Abstract

Viscumin (mistletoe lectin I, MLI) in concentrations of 10^-11-10^-7 M causes endoplasmic reticulum stress and triggers unfolded protein response, a modulator of antitumor immunity, in target cells.

Keywords: MLI; UPR; endoplasmic reticulum stress; ribosome-inactivating protein; viscumin.

MeSH terms

Animals
Caco-2 Cells
Cell Line, Tumor
Endoplasmic Reticulum Stress* / drug effects
Humans
Injections, Subcutaneous
Male
Mice
Plant Lectins / administration & dosage
Plant Lectins / pharmacokinetics
Plant Lectins / pharmacology
Ribosome Inactivating Proteins, Type 2 / administration & dosage
Ribosome Inactivating Proteins, Type 2 / pharmacokinetics*
Ribosome Inactivating Proteins, Type 2 / pharmacology
Toxins, Biological / administration & dosage
Toxins, Biological / pharmacokinetics*
Toxins, Biological / pharmacology
Unfolded Protein Response / drug effects

Substances

Plant Lectins
Ribosome Inactivating Proteins, Type 2
Toxins, Biological
mistletoe lectin I