Viral-specific T-cell response in hemorrhagic cystitis after haploidentical donor stem cell transplantation

Nopporn Apiwattanakul; Suradej Hongeng; Usanarat Anurathapan; Samart Pakakasama; Supanart Srisala; Chonnamet Techasaensiri; Borje S Andersson

doi:10.1111/tid.12775

Viral-specific T-cell response in hemorrhagic cystitis after haploidentical donor stem cell transplantation

Transpl Infect Dis. 2017 Dec;19(6). doi: 10.1111/tid.12775. Epub 2017 Oct 25.

Authors

Nopporn Apiwattanakul¹, Suradej Hongeng¹, Usanarat Anurathapan¹, Samart Pakakasama¹, Supanart Srisala², Chonnamet Techasaensiri¹, Borje S Andersson³

Affiliations

¹ Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
² Section for Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
³ Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 28865164
DOI: 10.1111/tid.12775

Abstract

Viral hemorrhagic cystitis (HC) after hematopoietic stem cell transplantation (HSCT) can be devastating. Standard treatment modalities have not been well established, but immune reconstitution may be necessary for sustained viral clearance. We studied five pediatric patients who developed viral HC after haplo-identical HSCT. All patients developed virus-specific CD4- and CD8-positive T cells, and the emergence of these viral-specific T cells was temporally associated with successful viral clearance.

Keywords: pediatric; post-transplant hemorrhagic cystitis; stem cell transplantation; viral-specific T cells.

MeSH terms

Adenoviridae / immunology
Adenoviridae / isolation & purification
Adenoviridae Infections / immunology
Adenoviridae Infections / virology
Adolescent
Antiviral Agents / therapeutic use
BK Virus / immunology
BK Virus / isolation & purification
CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / virology
CD8-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / virology
Child
Child, Preschool
Cystitis / blood
Cystitis / drug therapy
Cystitis / immunology*
Cystitis / virology
Female
Graft vs Host Disease / immunology
Graft vs Host Disease / therapy
Hematopoietic Stem Cell Transplantation / adverse effects*
Hemorrhage / blood
Hemorrhage / drug therapy
Hemorrhage / immunology*
Hemorrhage / virology
Humans
Immunity, Cellular*
Immunosuppressive Agents / adverse effects
Male
Polyomavirus Infections / immunology
Polyomavirus Infections / virology
Postoperative Complications / blood
Postoperative Complications / drug therapy
Postoperative Complications / immunology*
Postoperative Complications / virology
Transplantation, Homologous / adverse effects
Tumor Virus Infections / immunology
Tumor Virus Infections / virology
Viral Load / immunology

Substances

Antiviral Agents
Immunosuppressive Agents