Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation

Alan J Ryan; Hugh S O'Neill; Garry P Duffy; Fergal J O'Brien

doi:10.1016/j.coph.2017.07.013

Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation

Curr Opin Pharmacol. 2017 Oct:36:66-71. doi: 10.1016/j.coph.2017.07.013. Epub 2017 Aug 31.

Authors

Alan J Ryan¹, Hugh S O'Neill², Garry P Duffy³, Fergal J O'Brien⁴

Affiliations

¹ Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
² Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
³ Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland; Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland. Electronic address: [email protected].
⁴ Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland. Electronic address: [email protected].

PMID: 28865291
DOI: 10.1016/j.coph.2017.07.013

Abstract

Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.

Publication types

Review

MeSH terms

Animals
Foreign Bodies
Foreign-Body Reaction / prevention & control*
Humans
Islets of Langerhans
Islets of Langerhans Transplantation / instrumentation*
Polymers / administration & dosage
Polymers / chemistry

Substances

Polymers