Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

Jorge de la Rosa; Julia Weber; Roland Rad; Allan Bradley; Juan Cadiñanos

doi:10.1080/23723556.2017.1325550

Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

Mol Cell Oncol. 2017 May 4;4(4):e1325550. doi: 10.1080/23723556.2017.1325550. eCollection 2017.

Authors

Jorge de la Rosa^{1

2

3}, Julia Weber^{4

5}, Roland Rad^{1

4

5}, Allan Bradley¹, Juan Cadiñanos^{1

2}

Affiliations

¹ The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.
² Instituto de Medicina Oncológica y Molecular de Asturias (IMOMA), Oviedo, Spain.
³ Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.
⁴ Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.
⁵ German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Abstract

We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.

Keywords: AKAP13; CELF2; PARD3; PTEN; Sleeping Beauty; WAC; ZBTB20; prostate cancer; transposon; tumor suppressor gene.