Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Org Biomol Chem. 2017 Sep 26;15(37):7758-7764. doi: 10.1039/c7ob02069d.

Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.