Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation

Susan J Clark; Peter L Molloy

doi:10.1016/j.ccell.2017.08.016

Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation

Cancer Cell. 2017 Sep 11;32(3):278-280. doi: 10.1016/j.ccell.2017.08.016.

Authors

Susan J Clark¹, Peter L Molloy²

Affiliations

¹ Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 1466, Australia. Electronic address: [email protected].
² CSIRO Health and Biosecurity, PO Box 52, North Ryde, NSW 1670, Australia.

PMID: 28898692
DOI: 10.1016/j.ccell.2017.08.016

Abstract

How genetic and epigenetic events synergize to generate the oncogenic state is not well understood. In this issue of Cancer Cell, Vaz et al. provide compelling evidence that exposure to chronic cigarette smoke causes progressive epigenetic alterations that prime for key genetic events to drive the development of lung cancer.

Publication types

Comment

MeSH terms

Carcinogenesis
Humans
Lung
Lung Neoplasms
Mutation
Nicotiana*
Smoke*

Substances

Smoke