Clinical evaluation of the newly formatted lateral-flow device for invasive pulmonary aspergillosis

Mycoses. 2018 Jan;61(1):40-43. doi: 10.1111/myc.12704. Epub 2017 Oct 13.

Abstract

The study evaluated the newly formatted Aspergillus-specific lateral-flow-device (LFD), and compared its performance to the original prototype "old" LFD test using BALF samples from 28 patients (14 patients with probable/proven invasive pulmonary aspergillosis [IPA] and 14 patients with no evidence for IPA). A total of 10/14 (71%) of BALF samples from patients with probable/proven IPA resulted positive with the new LFD, including 8/9 with true-positive and 2/5 with false-negative results with the old LFD. All 14 samples from patients without IPA resulted negative with the new LFD; specificity of the new LFD was significantly improved compared to the old LFD.

Keywords: Haematological malignancy; bronchoalveolar lavage; galactomannan; intensive care unit; point-of-care.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Bronchoalveolar Lavage Fluid / microbiology*
  • Case-Control Studies
  • Chromatography, Affinity / instrumentation*
  • Chromatography, Affinity / methods
  • Female
  • Galactose / analogs & derivatives
  • Humans
  • Intensive Care Units / statistics & numerical data
  • Invasive Pulmonary Aspergillosis / diagnosis*
  • Invasive Pulmonary Aspergillosis / immunology
  • Invasive Pulmonary Aspergillosis / microbiology
  • Male
  • Mannans / immunology
  • Middle Aged
  • Point-of-Care Systems*
  • Prospective Studies
  • Sensitivity and Specificity

Substances

  • Mannans
  • galactomannan
  • Galactose