A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects

Affiliations

• ¹ Clinical Immunology Research Laboratory, Department of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium; Department of Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium; Center for Medical Genetics, Ghent University and Ghent University Hospital, Ghent, Belgium; Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium; Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
• ² Immunology Service, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md.
• ³ Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium; Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
• ⁴ Hematology Section, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md.
• ⁵ Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Ghent University Hospital, Ghent, Belgium.
• ⁶ Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium.
• ⁷ Clinical Immunology Research Laboratory, Department of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium; Department of Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium; Center for Medical Genetics, Ghent University and Ghent University Hospital, Ghent, Belgium; Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
• ⁸ Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Northern Centre for Bone Marrow Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
• ⁹ Department of Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium; Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
• ¹⁰ Center for Medical Genetics, Ghent University and Ghent University Hospital, Ghent, Belgium; Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
• ¹¹ Clinical Immunology Research Laboratory, Department of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium; Department of Pediatrics, Division of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium; Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
• ¹² Clinical Immunology Research Laboratory, Department of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium; Center for Primary Immunodeficiency, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium; Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium; Department of Internal Medicine, Ghent University, Ghent, Belgium. Electronic address: [email protected].