Portal vein thrombosis (PVT) has been recently documented after a variety of laparoscopic surgeries. Although it is well established in splenectomies, its prevalence in other laparoscopic procedures is rare. PVT in colectomies has been associated with inflammatory processes, such as ulcerative colitis and diverticulitis. We report a case of postoperative PVT following a total abdominal colectomy for colonic inertia. A 27-year-old female underwent an uneventful elective laparoscopic total colectomy with ileorectal anastomosis for colonic inertia, and presented on postoperative day (POD) 3 with obstipation, abdominal distention and emesis. Her abdominal pain increased on POD 4 and computed tomography revealed PVT. PVT following laparoscopic surgery is rare in cases not involving the spleen. Although previously seen in colectomies for inflammatory conditions, it can present after colonic inertia. A high index of suspicion should be maintained to diagnosis this rare complication.