Abstract
In Italy in 2016, acute flaccid myelitis developed in a woman who had received a hematopoietic stem cell transplant. Enterovirus D68 viral genome was detected in respiratory and cerebrospinal fluid samples, and the viral protein 1 sequence clustered with lineage B3. Immunocompromised adults may be at risk for enterovirus D68-associated neurologic complications.
Keywords:
Enterovirus D68; Italy; VP1 sequencing; acute flaccid myelitis; central nervous system infection; human; immunocompromised patient; molecular epidemiology; viruses.
MeSH terms
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Acute Disease
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Enterovirus D, Human / classification
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Enterovirus D, Human / genetics
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Enterovirus D, Human / isolation & purification
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Enterovirus D, Human / pathogenicity*
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Enterovirus Infections / etiology
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Enterovirus Infections / immunology*
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Enterovirus Infections / pathology
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Enterovirus Infections / virology
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Fatal Outcome
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Female
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Genotype
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Humans
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Immunocompromised Host*
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Immunosuppressive Agents / therapeutic use*
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Italy
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Lymphoma, Large B-Cell, Diffuse / immunology
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large B-Cell, Diffuse / therapy
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Lymphoma, Non-Hodgkin / immunology
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Lymphoma, Non-Hodgkin / pathology
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Lymphoma, Non-Hodgkin / therapy
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Middle Aged
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Myelitis
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Phylogeny
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Transplantation, Homologous