Lnc'ing Id2 to ILC1

Mengxi Sun; Barbara L Kee

doi:10.1016/j.immuni.2017.08.019

Lnc'ing Id2 to ILC1

Immunity. 2017 Sep 19;47(3):389-390. doi: 10.1016/j.immuni.2017.08.019.

Authors

Mengxi Sun¹, Barbara L Kee²

Affiliations

¹ Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.
² Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: [email protected].

PMID: 28930650
DOI: 10.1016/j.immuni.2017.08.019

Abstract

The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a long non-coding RNA.

Publication types

Comment

MeSH terms

Humans
Immunity, Innate / genetics*
Lymphocytes / immunology*
RNA, Long Noncoding
Regulatory Sequences, Nucleic Acid

Substances

RNA, Long Noncoding