Abstract
A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus into one that would induce an acute form of immunodeficiency. The data suggest that acutely pathogenic viruses may be selected against by current methods for isolation of the human and simian immunodeficiency viruses.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome
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Amino Acid Sequence
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Animals
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Base Sequence
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Bone Marrow / microbiology
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Cats
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Cloning, Molecular*
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DNA, Viral / genetics
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Humans
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Immunologic Deficiency Syndromes / etiology*
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Immunologic Deficiency Syndromes / microbiology
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Leukemia Virus, Feline / genetics*
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Leukemia Virus, Feline / pathogenicity
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Molecular Sequence Data
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Mutation
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Polymorphism, Restriction Fragment Length
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Transfection
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Virus Replication