Complement factor H-related proteins in IgA nephropathy-sometimes a gentle nudge does the trick

Joshua M Thurman; Jennifer Laskowski

doi:10.1016/j.kint.2017.05.025

Complement factor H-related proteins in IgA nephropathy-sometimes a gentle nudge does the trick

Kidney Int. 2017 Oct;92(4):790-793. doi: 10.1016/j.kint.2017.05.025.

Authors

Joshua M Thurman¹, Jennifer Laskowski²

Affiliations

¹ Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: [email protected].
² Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

PMID: 28938951
DOI: 10.1016/j.kint.2017.05.025

Abstract

Complement activation probably contributes to glomerular inflammation and damage in IgA nephropathy. In this issue, 2 groups report that levels of factor H-related protein 1 are elevated in patients with IgA nephropathy and correlate with disease progression. These studies provide new evidence that the complement cascade is important to the pathogenesis of this disease. These results also suggest that factor H-related protein 1 levels may be useful for identifying those patients at high risk of disease progression.

Publication types

Comment

MeSH terms

Complement Activation
Complement C3
Complement Factor H*
Complement System Proteins
Disease Progression
Glomerulonephritis, IGA*
Humans
Kidney Glomerulus

Substances

Complement C3
Complement Factor H
Complement System Proteins