Objective: To evaluate the effect and safety of phloroglucinol combined with parecoxib on cystospasm after transurethral resection of the prostate (TURP).
Methods: We conducted a prospective randomized case-control study on 98 patients treated by TURP. After operation, the patients were randomly assigned to a treatment (n=50) and a control group (n=48), the former treated by intravenous injection of 80 mg phloroglucinol qd plus 40 mg parecoxib bid while the latter given 80 mg phloroglucinol only, both for 3 successive days. Then we recorded the frequency and duration of cystospasm, visual analogue scales (VAS), adverse reactions, post-operative bladder irrigation time, catheter-indwelling time, and hospital stay and compared them between the two groups of patients.
Results: Compared with the controls, the patients in the treatment group showed a significantly lower frequency of cystospasm (［1.95±0.14］ vs ［0.70±0.65］ times, P<0.01), duration of cystospasm (［0.44±0.21］ vs ［0.12±0.14］ min, P<0.01), and VAS score (2.70±1.80 vs 1.90±1.30, P<0.01) at 48－72 hours after TURP, but no statistically significant differences were found between the control and treatment groups in the post-operative bladder irrigation time (［2.75±0.87］ vs ［2.64±0.83］ d, P>0.05), catheter-indwelling time (［3.52±0.32］ vs ［3.44±0.42］ d, P>0.05), and hospital stay (［5.23±0.81］ vs ［5.10±0.73］ d, P>0.05), and no obvious adverse reactions were observed in either of the two groups.
Conclusions: Phloroglucinol combined with parecoxib is more effective and safer than phloroglucinol alone in relieving postoperative cystospasm after TURP.
目的: 观察间苯三酚联合帕瑞昔布治疗经尿道前列腺电切术(TURP)后膀胱痉挛的有效性与安全性。方法: 采用前瞻性随机病例对照的方法进行研究，纳入接受TURP的患者98例，随机分为试验组与对照组。试验组50例,术后连续3 d予以间苯三酚联合帕瑞昔布治疗（间苯三酚80 mg,1次/d+帕瑞昔布40 mg，2次/d）；对照组48例,单独予以间苯三酚80mg治疗。观察并记录两组患者住院期间出现膀胱痉挛的次数、持续时间、疼痛视觉模拟评分(VAS)及不良反应，同时记录术后膀胱冲洗转淡时间、术后导尿管留置时间及术后住院时间。结果: 试验组术后3 d内膀胱痉挛发作次数［(0.70±0.65)次 vs (1.95±0.41)次］、膀胱痉挛持续时间［(0.12±0.14) min vs (0.44±0.21) min］、VAS痛觉评分［(1.90±1.30) 分 vs (2.70±1.80)分］均显著低于对照组（P均<0.01），但两组术后膀胱冲洗转淡时间［(2.64±0.83) d vs (2.75±0.87) d］、术后导尿管留置时间［(3.44±0.42) d vs (3.52±0.32) d］及术后住院时间［(5.10±0.73) d vs (5.23±0.81)d］比较无统计学差异(P均>0.05)。试验组与对照组均未发现明显不良反应。结论:与间苯三酚单药治疗相比，间苯三酚联合帕瑞昔布可更有效地缓解TURP术后膀胱痉挛，并且无明显并发症发生。.
Keywords: benign prostate hyperplasia; cystospasm; parecoxib; phloroglucinol; transurethral resection of the prostate.