Multicenter outcomes of robotic reconstruction during the early learning curve for minimally-invasive pancreaticoduodenectomy

HPB (Oxford). 2018 Feb;20(2):155-165. doi: 10.1016/j.hpb.2017.08.032. Epub 2017 Sep 29.

Abstract

Background: Perceived excess morbidity during the early learning curve of minimally-invasive pancreaticoduodenectomy (MIPD) has limited widespread adoption. It was hypothesized that robot-assisted reconstruction (RA) after MIPD allows anastomotic outcomes equivalent to open pancreaticoduodenectomy (PD).

Methods: Intent to treat analysis of centrally audited data accrued during early adoption of RA-MIPD at five centers.

Results: CUSUM analysis of operating times at each center identified 92 RA-MIPD during the early learning curve. Mean age was 65 ± 12 years with body mass index 25.8 ± 5.0. Surgical indications included malignant (60%) and premalignant (38%) lesions. Median operating time was 504 min (interquartile range 133) with 242 ml median estimated blood loss (IQR 398) and twelve (13%) conversions to open PD. Major complication rate (Clavien-Dindo III/IV) was 24% with 2 (2.2%) deaths and ten (10.9%) reoperations. Nine (9.9%) clinically significant pancreatic fistulae were observed (4 grade B; 5 grade C). Margin negative resection rate for malignancy was 90% (75% for PDA) with mean harvest of 16 ± 8 lymph nodes.

Conclusions: These multicenter data during the early learning curve for RA-MIPD do not demonstrate excess anastomotic morbidity compared to open. Further studies are required to determine whether surgeon proficiency and evolving technique improve anastomotic outcomes compared to open.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Loss, Surgical / prevention & control
  • Blood Transfusion
  • Clinical Competence
  • Conversion to Open Surgery
  • Female
  • Humans
  • Italy
  • Laparoscopy / adverse effects
  • Laparoscopy / methods*
  • Laparoscopy / mortality
  • Learning Curve*
  • Male
  • Middle Aged
  • Operative Time
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / surgery*
  • Pancreaticoduodenectomy / adverse effects
  • Pancreaticoduodenectomy / methods*
  • Pancreaticoduodenectomy / mortality
  • Plastic Surgery Procedures / adverse effects
  • Plastic Surgery Procedures / methods*
  • Plastic Surgery Procedures / mortality
  • Postoperative Complications / mortality
  • Postoperative Complications / surgery
  • Reoperation
  • Risk Factors
  • Robotic Surgical Procedures / adverse effects
  • Robotic Surgical Procedures / methods*
  • Robotic Surgical Procedures / mortality
  • Surgeons*
  • Time Factors
  • Treatment Outcome
  • United States