Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst

Amit Kumar; Noel Angel Espinosa-Jalapa; Gregory Leitus; Yael Diskin-Posner; Liat Avram; David Milstein

doi:10.1002/anie.201709180

Direct Synthesis of Amides by Dehydrogenative Coupling of Amines with either Alcohols or Esters: Manganese Pincer Complex as Catalyst

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14992-14996. doi: 10.1002/anie.201709180. Epub 2017 Oct 20.

Authors

Amit Kumar¹, Noel Angel Espinosa-Jalapa¹, Gregory Leitus², Yael Diskin-Posner², Liat Avram², David Milstein¹

Affiliations

¹ Department of Organic Chemistry, Weizmann Institute of Institution, Rehovot, 76100, Israel.
² Chemical Research Support, Weizmann Institute of Science, Rehovot, 76100, Israel.

PMID: 28967992
DOI: 10.1002/anie.201709180

Abstract

The first example of base-metal-catalysed synthesis of amides from the coupling of primary amines with either alcohols or esters is reported. The reactions are catalysed by a new manganese pincer complex and generate hydrogen gas as the sole byproduct, thus making the overall process atom-economical and sustainable.

Keywords: amides; amines; ligand design; manganese; structure elucidation.

Publication types

Research Support, Non-U.S. Gov't