Abstract
Brain perfusion was studied in 14 patients with acute encephalitis by use of 123I-iodoamphetamine or 99mTc-hexamethylpropyleneamine oxime and single photon emission computed tomography (SPECT), the first examination being made 4-11 days after onset of encephalitis symptoms. All 6 patients with herpes simplex virus encephalitis (HSVE) had strongly increased accumulation of radiotracer in the affected temporal lobe; in the remaining 8 results were normal. At the time of the first SPECT conventional CT images were normal in all patients. The SPECT abnormality in HSVE gradually converted over 4-10 weeks from increased tracer accumulation to greatly subnormal accumulation. Brain perfusion SPECT may be helpful in the early diagnosis of HSVE.
MeSH terms
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Acute Disease
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Adult
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Amphetamines
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Antibodies, Viral / analysis
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Diagnosis, Differential
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Electroencephalography
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Encephalitis / cerebrospinal fluid
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Encephalitis / diagnostic imaging*
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Encephalitis / etiology
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Encephalitis / physiopathology
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Female
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Follow-Up Studies
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Herpes Simplex / cerebrospinal fluid
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Herpes Simplex / complications
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Herpes Simplex / diagnostic imaging*
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Herpes Simplex / physiopathology
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Humans
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Iodine Radioisotopes
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Male
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Middle Aged
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Organometallic Compounds
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Oximes
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Radionuclide Imaging
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Simplexvirus / immunology
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Technetium
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Technetium Tc 99m Exametazime
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Temporal Lobe*
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Tomography, Emission-Computed*
Substances
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Amphetamines
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Antibodies, Viral
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Iodine Radioisotopes
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Organometallic Compounds
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Oximes
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4-iodoamphetamine
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Technetium Tc 99m Exametazime
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Technetium