Data of PCL-b-P(MMA-DMAEMA)2 characterization and related assays

Camila Franco; Michelli Barcelos Antonow; Aline Beckenkamp; Andréia Buffon; Taise Ceolin; Marli Luiza Tebaldi; Gustavo Pozza Silveira; Silvia Stanisçuaski Guterres; Adriana Raffin Pohlmann

doi:10.1016/j.dib.2017.09.010

Data of PCL-b-P(MMA-DMAEMA)₂ characterization and related assays

Data Brief. 2017 Sep 19:15:111-126. doi: 10.1016/j.dib.2017.09.010. eCollection 2017 Dec.

Affiliations

¹ Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre 90610-000, RS, Brazil.
² Programa de Pós-Graduação em Nanotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752. Porto Alegre, 90610-000, RS, Brazil.
³ Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, RS, Brazil.

Abstract

The data presented here are related to the research paper entitled "PCL-b-P(MMA-co-DMAEMA)₂ new triblock copolymer for novel pH-sensitive nanocapsules intended for drug delivery to tumors" by Franco et al. [1]. Characterization data of PCL-diol, macroinitiator Br-PCL-Br, homopolymers (PMMA and PDMAEMA) and copolymers (batch 1 and batch 2) analyzed by FTIR, SEC and NMR, as well as, characterization of PCL-NS formulation by laser diffraction and DLS analysis, initial nanocapsule formulations and 1C-NC and 2C-NC formulations, including hydrodynamic diameter at different pH media, and DMSO cytotoxicity.

Keywords: Cell viability; Methacrylic copolymer; Nanocapsules; Polycaprolactone; pH-sensitive.