Abstract
The synthesis of a series of oxypropanolamines of 3,4-dihydro-3-oxo-2H(1,4)benzothiazine is reported. Some of these compounds proved more potent than propranolol and carteolol as beta-adrenergic blocking agents in in vitro tests. The 8-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydro-3-oxo-2H(1,4) benzothiazine fumarate (XVI a), which gave better results, confirmed its remarkable activity in in vivo tests.
MeSH terms
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Adrenergic beta-Antagonists / chemical synthesis*
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Animals
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Chemical Phenomena
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Chemistry
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Female
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Guinea Pigs
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Heart Rate / drug effects
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In Vitro Techniques
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Isoproterenol / antagonists & inhibitors
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Male
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Mice
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Propanolamines / chemical synthesis*
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Propanolamines / pharmacology
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Propanolamines / toxicity
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Rats
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Rats, Inbred SHR
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Thiazines / chemical synthesis*
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Thiazines / pharmacology
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Thiazines / toxicity
Substances
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Adrenergic beta-Antagonists
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Propanolamines
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Thiazines
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Isoproterenol