Bacterial overgrowth, dysbiosis, inflammation, and dysmotility in the Cystic Fibrosis intestine

Jill Dorsey; Tanja Gonska

doi:10.1016/j.jcf.2017.07.014

Bacterial overgrowth, dysbiosis, inflammation, and dysmotility in the Cystic Fibrosis intestine

J Cyst Fibros. 2017 Nov:16 Suppl 2:S14-S23. doi: 10.1016/j.jcf.2017.07.014.

Authors

Jill Dorsey¹, Tanja Gonska²

Affiliations

¹ Pediatric Gastroenterology, Hepatology, and Nutrition, Nemours Children's Specialty Care, Jacksonville, FL, United States. Electronic address: [email protected].
² Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

PMID: 28986022
DOI: 10.1016/j.jcf.2017.07.014

Abstract

Gastrointestinal disease in Cystic Fibrosis (CF) is caused by defective chloride and bicarbonate transport in intestinal cells leading to reduced intraluminal fluidity, increased mucous viscosity and consequently development of intestinal inflammation, dysbiosis and often times dysmotility. This triad is also referred to as the "CF gut". A diagnosis is mainly based on clinical observation and treatment is often times decided empirically. This review of the literature should provide CF caregivers with some tools to identify intestinal inflammation, dysbiosis and dysmotility as possible cause for their patient's gastrointestinal complaints and provide an overview of our current approach to its management.

Keywords: Bacterial overgrowth; CF intestine; Dybiosis; Dysmotility; Intestinal inflammation; Probiotics; SIBO.

Publication types

Review

MeSH terms

Cystic Fibrosis / complications*
Dysbiosis / etiology
Gastrointestinal Diseases* / etiology
Gastrointestinal Diseases* / microbiology
Gastrointestinal Diseases* / physiopathology
Gastrointestinal Motility*
Humans
Inflammation / etiology
Patient Care Management / methods*