Functional disability and other health-related quality-of-life domains: points to consider for clinical trials in systemic sclerosis

Dinesh Khanna; Ron D Hays; Daniel E Furst

doi:10.1093/rheumatology/kex193

Functional disability and other health-related quality-of-life domains: points to consider for clinical trials in systemic sclerosis

Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v17-v22. doi: 10.1093/rheumatology/kex193.

Authors

Dinesh Khanna¹, Ron D Hays², Daniel E Furst³

Affiliations

¹ Department of Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI.
² Department of General Internal Medicine and Health Services Research.
³ David Geffen School of Medicine, Los Angeles, CA, USA.

Abstract

Patients with SSc have the highest mortality among the rheumatic diseases. In addition, SSc is associated with disfigurement, hand contractures, fatigue, poor sleep, severe RP with numbness and tingling of the fingers can lead to decrements in quality of life. This Points to Consider article provides practical considerations for design of trials for functional disability and other health-related quality-of-life issues.

Keywords: clinical trials; function; quality of life; scleroderma.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Clinical Trials as Topic*
Disability Evaluation*
Humans
Motor Activity / physiology*
Quality of Life*
Scleroderma, Systemic / diagnosis
Scleroderma, Systemic / physiopathology
Scleroderma, Systemic / rehabilitation*
Severity of Illness Index

Grants and funding

K24 AR063120/AR/NIAMS NIH HHS/United States