Have we pushed the needle for treatment of Type 1 diabetes?

Curr Opin Immunol. 2017 Dec:49:44-50. doi: 10.1016/j.coi.2017.09.004. Epub 2017 Oct 6.

Abstract

Studies with immunologics have shown that the natural history of Type 1 diabetes can be modified. These studies have targeted key mediators of the disease and recent analyses, together with studies in preclinical models have identified mechanisms that may be involved in the clinical effects. Several issues remain including specificity of the interventions, adverse effects of the treatments, and duration of their effects. Future studies are likely to include more specific approaches with agents such as cell therapies with selected immune regulatory subsets, antigen specific therapies, and combinations of agents with complementary mechanisms of activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantigens / immunology
  • Autoantigens / therapeutic use*
  • Biological Products / therapeutic use*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / therapy*
  • Disease Models, Animal
  • Humans
  • Immune Tolerance
  • Immunotherapy / methods*
  • Insulin-Secreting Cells / drug effects
  • Insulin-Secreting Cells / pathology*
  • Molecular Targeted Therapy

Substances

  • Autoantigens
  • Biological Products