Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure

Jessica R Allegretti; Dina Kao; Jessica Sitko; Monika Fischer; Zain Kassam

doi:10.1093/cid/cix684

Early Antibiotic Use After Fecal Microbiota Transplantation Increases Risk of Treatment Failure

Clin Infect Dis. 2018 Jan 6;66(1):134-135. doi: 10.1093/cid/cix684.

Authors

Jessica R Allegretti^{1

2}, Dina Kao³, Jessica Sitko², Monika Fischer⁴, Zain Kassam⁵

Affiliations

¹ Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
² Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.
³ Division of Gastroenterology, University of Alberta Zeidler Ledcor Centre, Edmonton, Canada.
⁴ Division of Gastroenterology, Indiana University School of Medicine, Indianapolis.
⁵ OpenBiome, Somerville, Massachusetts.

PMID: 29020157
DOI: 10.1093/cid/cix684

Abstract

Antibiotic use within the first 8 weeks after fecal microbiota transplantation (FMT) may disrupt microbial engraftment and limit FMT effectiveness. We aimed to assess the burden of antibiotic use within 8 weeks of FMT and its impact on FMT efficacy.

Keywords: Antibiotics; Clostridium difficile; Diarrhea; Fecal transplant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Fecal Microbiota Transplantation*
Female
Humans
Male
Middle Aged
Retrospective Studies
Risk Assessment
Time Factors
Treatment Failure

Substances

Anti-Bacterial Agents