Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Arthur R Celestin; Stephen R Odom; Konstantia Angelidou; Scott R Evans; Raul Coimbra; Christopher A Guidry; Joseph Cuschieri; Kaysie L Banton; Patrick J O'Neill; Reza Askari; Nicholas Namias; Therèse M Duane; Jeffrey A Claridge; E Patchen Dellinger; Robert A Sawyer; Charles H Cook

doi:10.1093/cid/cix569

Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Clin Infect Dis. 2017 Oct 16;65(9):1577-1579. doi: 10.1093/cid/cix569.

Authors

Arthur R Celestin¹, Stephen R Odom¹, Konstantia Angelidou², Scott R Evans², Raul Coimbra³, Christopher A Guidry⁴, Joseph Cuschieri⁵, Kaysie L Banton⁶, Patrick J O'Neill⁷, Reza Askari⁸, Nicholas Namias⁹, Therèse M Duane¹⁰, Jeffrey A Claridge¹¹, E Patchen Dellinger⁵, Robert A Sawyer¹², Charles H Cook¹

Affiliations

¹ Department of Surgery, Beth Israel Deaconess Medical Center.
² Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
³ Department of Surgery, University of California, San Diego Medical Center.
⁴ Department of Surgery, University of Texas Medical Branch, Galveston.
⁵ Department of Surgery, University of Washington School of Medicine, Seattle.
⁶ Department of Surgery, University of Minnesota, Minneapolis.
⁷ Department of Surgery, University of Arizona School of Medicine, Phoenix.
⁸ Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
⁹ Department of Surgery, University of Miami Health System, Florida.
¹⁰ Department of Surgery, John Peter Smith Hospital, Fort Worth, Texas.
¹¹ Department of Surgery, MetroHealth System, Case Western Reserve University, Cleveland, Ohio.
¹² Department of Surgery, University of Virginia Health System, Charlottesville.

Abstract

Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.

Keywords: antibiotic resistance; desirability of outcome ranking; duration of antibiotic therapy; intra-abdominal infection; surgical infection.

MeSH terms

Anti-Bacterial Agents* / administration & dosage
Anti-Bacterial Agents* / therapeutic use
Humans
Intraabdominal Infections / drug therapy*
Practice Guidelines as Topic*
Retrospective Studies
Treatment Outcome

Substances

Anti-Bacterial Agents