Hemodynamic parameters and baroreflex sensitivity during head-up tilt test in patients with neurally mediated syncope

Background: We aimed to investigate differences in hemodynamic parameters and the role of baroreflex sensitivity (BRS) in patients with a history of neurally mediated syncope (NMS) compared with a control group.

Methods: Hemodynamic parameters and BRS were continuously measured noninvasively using a Finometer at rest and during passive head-up tilt test (HUT) in patients with a history of NMS (n = 55) and a control group (n = 77). The tilting period was divided into pretest (resting supine position), initial (first 3 minutes of tilting), last (last 3 minutes of tilting), and recovery (3 minutes after tilting was complete) periods.

Results: Decrease in systolic blood pressure (- 14.7 ± 15.7 mm Hg vs - 7.6 ± 14.3 mm Hg, P < 0.01) was more prominent and increase in total systemic peripheral resistance was significantly smaller (67.6 ± 418.7 dyn.s/cm⁵ vs 189.4 ± 261.0 dyn.s/cm⁵ , P = 0.04) from the initial to the last period of HUT in the patient group compared with the control group. BRS was significantly higher during the pretest period (20.1 ± 10.9 ms/mm Hg vs 13.0 ± 8.1 ms/mm Hg, P < 0.01) in the patient group, while the decrease in BRS from the pretest to the initial period was greater (-8.5 ± 6.0 ms/mm Hg vs - 3.2 ± 4.1 ms/mm Hg, P = 0.01).

Conclusions: Dysfunctional BRS in response to orthostatic stress might be involved in pathological autonomic cardiac modulation of NMS.