Abstract
The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.
Keywords:
ATP-dependent chromatin remodeler; Chromatin reprogramming; Epigenetic eraser; Epigenetic reader; Epigenetic writer; Gene regulation; Hypoxia-inducible factor.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Epigenesis, Genetic*
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HeLa Cells
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Histone Deacetylase 1 / genetics*
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Histone Deacetylase 1 / metabolism
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Humans
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Hypoxia / genetics*
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Hypoxia / metabolism
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Hypoxia / pathology
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Oxygen / pharmacology
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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Protein Stability
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Transcription, Genetic
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Von Hippel-Lindau Tumor Suppressor Protein / genetics*
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Von Hippel-Lindau Tumor Suppressor Protein / metabolism
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p300-CBP Transcription Factors / genetics*
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p300-CBP Transcription Factors / metabolism
Substances
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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Protein Isoforms
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p300-CBP Transcription Factors
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Von Hippel-Lindau Tumor Suppressor Protein
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HDAC1 protein, human
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Histone Deacetylase 1
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VHL protein, human
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Oxygen