A lignan with glucose uptake activity in 3T3-L1 adipocytes from the stem bark of Knema patentinervia

Muhammad Taher; Mohamed Zaffar Ali Mohamed Amiroudine; Juliana Md Jaffri; Mohamad Shahreen Amri; Deny Susanti; Shafida Abd Hamid; Mohamad Fazlin Rezali; Choudhury Mahmood Hassan; Roger W Read; Qamaruddin Ahmed; Farediah Ahmad

A lignan with glucose uptake activity in 3T3-L1 adipocytes from the stem bark of Knema patentinervia

Pak J Pharm Sci. 2017 Jul;30(4):1335-1339.

Affiliations

¹ Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia.
² Department of Chemistry, Faculty of Science, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia.
³ SIRIM Berhad (National Metrology Laboratory), Lot PT, Bandar Baru Salak Tinggi, Sepang, Selangor, Malaysia.
⁴ Manarat International University, Road No 106, Gulshan-2, Dhaka, Bangladesh.
⁵ The School of Chemistry, The University of New South Wales, UNSW Sydney NSW, Australia.
⁶ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang, Malaysia.
⁷ Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.

PMID: 29039334

Abstract

A new naturally occurring dibenzylbutyrolactone lignan named isocubebinic ether has been isolated from Knema patentinervia. The structure was established by spectroscopic methods, which include Ultraviolet, Infrared, Nuclear Magnetic Resonance and Mass Spectrometry. The compound showed activity in the stimulation of glucose uptake by 3T3-L1 adipocytes.

MeSH terms

3T3 Cells
Adipocytes / metabolism*
Animals
Deoxyglucose / metabolism
Glucose / metabolism*
Lignans / chemistry
Lignans / pharmacology*
Mice
Molecular Structure
Myristicaceae / chemistry*
Plant Bark / chemistry
Tritium / metabolism

Substances

Lignans
Tritium
Deoxyglucose
Glucose