Intussusception Rate Among Under-Five-Children Before Introduction of Rotavirus Vaccine in North India

J Trop Pediatr. 2018 Aug 1;64(4):326-335. doi: 10.1093/tropej/fmx073.

Abstract

Background: Baseline data on intussusception are needed to compare the intussusception rates following introduction of rotavirus vaccine.

Methods: A hospital-based bidirectional surveillance (retrospective from 2009 to 2012; and prospective from 2013 to 2015) was set up in a tertiary care hospital in Chandigarh, India, to enrol children <5 years of age admitted with intussusception as per Brighton's classification, to estimate the hospital admission rate. Incidence of intussusception among infants and children <5 years of age was also estimated.

Results: A total of 277 intussusception cases (96 retrospective; 181 prospective) were reported. Majority of cases were males (69.7%) and infants (72%). Median age at diagnosis was 10 months (interquartile range 6-12 months). Nearly 62% cases were treated surgically and 33% radiologically. Incidence was estimated to be 20/100 000 infants, and 5/100 000 children <5 years of age per year, in Chandigarh.

Conclusion: Intussusception surveillance system provided background hospital admission and incidence rate before rotavirus vaccine introduction in North India.

MeSH terms

  • Age Distribution
  • Child, Preschool
  • Female
  • Hospitalization / statistics & numerical data*
  • Humans
  • Immunization Programs
  • Incidence
  • India / epidemiology
  • Infant
  • Infant, Newborn
  • Intussusception / epidemiology*
  • Male
  • Population Surveillance
  • Prospective Studies
  • Retrospective Studies
  • Rotavirus Infections / epidemiology
  • Rotavirus Infections / prevention & control*
  • Rotavirus Vaccines / administration & dosage*
  • Rotavirus Vaccines / adverse effects*
  • Sex Distribution
  • Sex Ratio
  • Tertiary Care Centers
  • Vaccination / adverse effects*

Substances

  • Rotavirus Vaccines