Towards a balanced view of the bacterial tree of life

Microbiome. 2017 Oct 17;5(1):140. doi: 10.1186/s40168-017-0360-9.

Abstract

The bacterial tree of life has recently undergone significant expansion, chiefly from candidate phyla retrieved through genome-resolved metagenomics. Bypassing the need for genome availability, we present a snapshot of bacterial phylogenetic diversity based on the recovery of high-quality SSU rRNA gene sequences extracted from nearly 7000 metagenomes and all available reference genomes. We illuminate taxonomic richness within established bacterial phyla together with environmental distribution patterns, providing a revised framework for future phylogeny-driven sequencing efforts.

Keywords: Bacteria; Bacterial diversity; Candidate Phyla Radiation (CPR); Metagenomics; Microbial dark matter (MDM); Novel bacterial lineages; Small subunit (SSU) rRNA; Tree of life.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Archaea / classification
  • Bacteria / classification*
  • Bacteria / genetics
  • Genes, rRNA
  • Genetic Variation
  • Genome, Bacterial
  • Metagenome*
  • Metagenomics
  • Phylogeny*
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA

Substances

  • RNA, Ribosomal, 16S