From Oncogene Interference to Neutrophil Immune Modulation

Vincenzo Bronte

doi:10.1016/j.immuni.2017.10.005

From Oncogene Interference to Neutrophil Immune Modulation

Immunity. 2017 Oct 17;47(4):613-615. doi: 10.1016/j.immuni.2017.10.005.

Author

Vincenzo Bronte¹

Affiliation

¹ Verona University Hospital, Department of Medicine, Immunology Unit, Verona, Italy. Electronic address: [email protected].

PMID: 29045894
DOI: 10.1016/j.immuni.2017.10.005

Abstract

Oncogenes can aid tumor progression in a cancer cell-extrinsic way. In this issue of Immunity, Glodde et al. (2017) demonstrate that interference with c-MET tyrosine kinase receptor can relieve neutrophil-dependent immune suppression and unleash the effectiveness of immunotherapy even in the context of c-MET-independent tumors.

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MeSH terms

Humans
Immunotherapy
Neoplasms / genetics*
Neutrophils*
Oncogenes
Proto-Oncogene Proteins c-met / genetics

Substances

Proto-Oncogene Proteins c-met