Recurrence rate after cessation of nucleos(t)ide analogues remains high in clinical practice. According to current evidences, age, HBsAg level, HB VRNA level, time of consolidation therapy and HBV DNA load were considered to be associated with off-treatment responses after cessation of nucleos(t)ide analogues. Combinative factors of several predictors might perform better in future accompanying with further studies of HBV related markers.
在临床实践中，很多研究结果显示核苷（酸）类似物停药复发率较高，根据已有的循证医学证据，患者年龄、HBsAg水平、HBV RNA水平、巩固治疗时间以及HBV DNA载量可能是核苷（酸）类似物停药复发的相关预测因素。随着HBV相关标志物的不断深入研究，多因素联合预测方式将会有助于做出更加合理的判断。.
Keywords: Hepatitis B, chronic; Nucleos(t)ide analogues; Off-treatment; Predictors.