Abstract
A comparison between the effects of H2 antagonists Cimetidine and Famotidine on the hemotoxicity of Cyclophosphamide in vivo in DBA/2NCrBl mice is described. Hemotoxicity of anticancer drug was determined by peripheral blood leukocytes, bone marrow cells and bone marrow CFU-S, GM-CFC. Results show that Famotidine does not increase Cyclophosphamide hemotoxicity while Cimetidine enhances the toxicity of the anticancer drug only on normal pluripotent hemopoietic stem cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow / drug effects
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Bone Marrow / pathology
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Cell Survival / drug effects
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Cimetidine / pharmacology*
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Cyclophosphamide / toxicity*
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Famotidine
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Female
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / drug effects
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Hematopoietic Stem Cells / pathology*
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Histamine H2 Antagonists / pharmacology*
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Leukocyte Count / drug effects*
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Male
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Mice
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Mice, Inbred DBA
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Reference Values
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Thiazoles / pharmacology*
Substances
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Histamine H2 Antagonists
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Thiazoles
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Famotidine
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Cimetidine
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Cyclophosphamide