Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study
Blood
.
2018 Jan 11;131(2):263-265.
doi: 10.1182/blood-2017-06-790121.
Epub 2017 Nov 2.
Authors
Ali T Taher
1
,
Zeynep Karakas
2
,
Elena Cassinerio
3
,
Noppadol Siritanaratkul
4
,
Antonis Kattamis
5
,
Aurelio Maggio
6
,
Stefano Rivella
7
,
Norbert Hollaender
8
,
Bruyère Mahuzier
9
,
Brian Gadbaw
10
,
Yesim Aydinok
11
Affiliations
1
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
2
Department of Pediatric Hematology and Oncology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.
3
Università di Milano, Ca Granda Foundation Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
4
Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
5
First Department of Pediatrics, University of Athens, Athens, Greece.
6
Campus of Haematology Franco e Piera Cutino Azienda Ospedaliera Ospedali Riuniti Villa Sofia V. Cervello, Palermo, Italy.
7
Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
8
Novartis Pharma AG, Basel, Switzerland.
9
Novartis Pharma S.A.S., Rueil Malmaison, France.
10
Novartis Pharmaceuticals Corporation, East Hanover, NJ; and.
11
Ege University Hospital, Department of Pediatric Hematology and Oncology, Izmir, Turkey.
PMID:
29097381
PMCID:
PMC5757682
DOI:
10.1182/blood-2017-06-790121
No abstract available
Publication types
Letter
Comment
MeSH terms
Erythroid Cells
Erythropoiesis
Humans
Nitriles
Pyrazoles
Pyrimidines
Thalassemia*
beta-Thalassemia*
Substances
Nitriles
Pyrazoles
Pyrimidines
ruxolitinib
Grants and funding
R01 DK090554/DK/NIDDK NIH HHS/United States
R01 DK095112/DK/NIDDK NIH HHS/United States