Vitamin C: C-ing a New Way to Fight Leukemia

Katharina Schönberger; Nina Cabezas-Wallscheid

doi:10.1016/j.stem.2017.09.015

Vitamin C: C-ing a New Way to Fight Leukemia

Cell Stem Cell. 2017 Nov 2;21(5):561-563. doi: 10.1016/j.stem.2017.09.015.

Authors

Katharina Schönberger¹, Nina Cabezas-Wallscheid²

Affiliations

¹ Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
² Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Electronic address: [email protected].

PMID: 29100007
DOI: 10.1016/j.stem.2017.09.015

Abstract

Metabolic cues and (epi-)genetic factors are emerging regulators of hematopoietic stem cell (HSC) potency. Two new studies in Nature and Cell, from Agathocleous et al. (2017) and Cimmino et al. (2017), respectively, show that vitamin C regulates HSC function and suppresses leukemogenesis by modulating Tet2 activity.

Publication types

Comment

MeSH terms

Ascorbic Acid*
DNA-Binding Proteins
Dioxygenases
Disease Progression
Hematopoietic Stem Cells
Humans
Leukemia*
Proto-Oncogene Proteins

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
Dioxygenases
TET2 protein, human
Ascorbic Acid