Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force

J Schwarze; P Openshaw; A Jha; S R Del Giacco; D Firinu; O Tsilochristou; G Roberts; A Selby; C Akdis; I Agache; A Custovic; E Heffler; G Pinna; M Khaitov; A Nikonova; N Papadopoulos; A Akhlaq; U Nurmatov; H Renz; A Sheikh; C Skevaki

doi:10.1111/all.13333

Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force

Allergy. 2018 Jun;73(6):1151-1181. doi: 10.1111/all.13333. Epub 2018 Jan 26.

Authors

J Schwarze¹, P Openshaw², A Jha², S R Del Giacco³, D Firinu³, O Tsilochristou⁴, G Roberts⁵, A Selby⁵, C Akdis⁶, I Agache⁷, A Custovic⁸, E Heffler⁹, G Pinna¹⁰, M Khaitov¹¹, A Nikonova¹¹, N Papadopoulos^{12

13}, A Akhlaq¹⁴, U Nurmatov¹⁵, H Renz¹⁶, A Sheikh¹⁷, C Skevaki¹⁶

Affiliations

¹ Centre for Inflammation Research, The Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
² Respiratory Sciences, National Heart and Lung Institute, Imperial College London, London, UK.
³ Department of Medical Sciences and Public Health "M. Aresu", University of Cagliari, Cagliari, Italy.
⁴ Department of Pediatric Allergology, King's College, London, UK.
⁵ Faculty of Medicine, Southampton and David Hide Asthma and Allergy Centre, St Mary's Hospital, University of Southampton, Newport, Isle of Wight, UK.
⁶ Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
⁷ Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University Brasov, Brasov, Romania.
⁸ Department of Paediatrics, Imperial College London, London, UK.
⁹ Personalized Medicine, Asthma and Allergy Clinic, Department of Biomedical Sciences, Humanitas University, Milan, Italy.
¹⁰ Department of Medical Microbiology, National Kapodistrian University of Athens, Athens, Greece.
¹¹ National Research Center Institute of Immunology of Federal Medicobiological Agency, Moscow, Russia.
¹² Division of Infection, Inflammation & Respiratory Medicine, The University of Manchester, Manchester, UK.
¹³ Allergy Department, 2nd Paediatric Clinic, National Kapodistrian University of Athens, Athens, Greece.
¹⁴ Department of Health and Hospital Management, Institute of Business Management, Korangi Creek, Karachi, 75190, Pakistan.
¹⁵ Division of Population Medicine, School of Medicine, Cardiff University, the National Centre for Population Health and Wellbeing Research, Wales, UK.
¹⁶ Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen & Marburg, Marburg, Germany.
¹⁷ Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

PMID: 29105786
DOI: 10.1111/all.13333

Abstract

To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

Keywords: antivirals; heath care utilization; respiratory; vaccination; viral infection.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

Antiviral Agents / therapeutic use
Asthma / complications*
Asthma / epidemiology*
Cost of Illness
Global Health
Humans
Immunogenicity, Vaccine
Influenza Vaccines / administration & dosage
Influenza Vaccines / adverse effects
Influenza Vaccines / immunology
Influenza, Human / complications*
Influenza, Human / epidemiology*
Influenza, Human / prevention & control*
Influenza, Human / therapy
Patient Outcome Assessment
Public Health Surveillance
Treatment Outcome
Vaccination

Substances

Antiviral Agents
Influenza Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding