Reduced dorsolateral prefrontal cortex activation during affective Go/NoGo in violent schizophrenia patients: An fMRI study

Andràs Tikàsz; Stéphane Potvin; Stéphane Richard-Devantoy; Olivier Lipp; Sheilagh Hodgins; Pierre Lalonde; Ovidiu Lungu; Alexandre Dumais

doi:10.1016/j.schres.2017.11.011

Reduced dorsolateral prefrontal cortex activation during affective Go/NoGo in violent schizophrenia patients: An fMRI study

Schizophr Res. 2018 Jul:197:249-252. doi: 10.1016/j.schres.2017.11.011. Epub 2017 Nov 9.

Authors

Andràs Tikàsz¹, Stéphane Potvin¹, Stéphane Richard-Devantoy², Olivier Lipp¹, Sheilagh Hodgins³, Pierre Lalonde¹, Ovidiu Lungu⁴, Alexandre Dumais⁵

Affiliations

¹ Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada.
² Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychiatry, Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Canada.
³ Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Institut Philippe-Pinel de Montréal, Montreal, Canada.
⁴ Department of Psychiatry, University of Montreal, Montreal, Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, Canada; Centre for Research in Aging, Donald Berman Maimonides Geriatric Centre, Montreal, Canada.
⁵ Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Institut Philippe-Pinel de Montréal, Montreal, Canada. Electronic address: [email protected].

PMID: 29129509
DOI: 10.1016/j.schres.2017.11.011

Abstract

We investigated the influence of anger processing on cognitive control in male schizophrenia patients presenting violent behaviors. We recruited 23 patients without and 24 patients with (SCZ+V) a history of violent behaviors, as well as 22 healthy non-violent men. Participants were administered an affective (angry-neutral faces) Go/NoGo task while undergoing functional magnetic resonance imaging. We found a reduced activation in the dorsolateral prefrontal cortex in SCZ+V patients specifically when inhibiting a response while viewing angry faces. These results show an inability of SCZ+V to recruit a core region of the (inhibitory) cognitive control network in the context of anger.

Keywords: Anger; Cognitive control; Go/NoGo; Schizophrenia; Violence; fMRI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Anger / physiology*
Executive Function / physiology*
Facial Expression*
Functional Neuroimaging*
Humans
Inhibition, Psychological*
Magnetic Resonance Imaging
Male
Middle Aged
Prefrontal Cortex / diagnostic imaging
Prefrontal Cortex / physiopathology*
Psychomotor Performance / physiology
Schizophrenia / diagnostic imaging
Schizophrenia / physiopathology*
Violence*
Young Adult