Diagnosis and Management of Eosinophilic Esophagitis

Jeffrey M Wilson; Emily C McGowan

doi:10.1016/j.iac.2017.09.010

Diagnosis and Management of Eosinophilic Esophagitis

Immunol Allergy Clin North Am. 2018 Feb;38(1):125-139. doi: 10.1016/j.iac.2017.09.010. Epub 2017 Nov 6.

Authors

Jeffrey M Wilson¹, Emily C McGowan²

Affiliations

¹ Division of Allergy and Immunology, Department of Medicine, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA.
² Division of Allergy and Immunology, Department of Medicine, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, 501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Electronic address: [email protected].

Abstract

Unlike traditional food allergies, immunoglobulin E (IgE) is not a key mediator of eosinophilic esophagitis (EoE). Nonetheless, foods antigens are important triggers of EoE, and allergists play an important role in management of this chronic disease. This review addresses insights into the diagnosis and management as it relates to our evolving understanding about the pathogenesis of EoE.

Keywords: Elimination diet; Eosinophilic esophagitis; Food allergy; IgG4; Swallowed steroids.

Publication types

Review

MeSH terms

Allergens / immunology
Animals
Chronic Disease
Diet*
Eosinophilic Esophagitis / diagnosis*
Eosinophilic Esophagitis / therapy
Food Hypersensitivity / immunology*
Food*
Humans
Immunoglobulin G / metabolism*
Steroids / therapeutic use

Substances

Allergens
Immunoglobulin G
Steroids

Grants and funding

K23 AI123596/AI/NIAID NIH HHS/United States