Salmonella enterica serovar Typhi Producing CTX-M-15 Extended Spectrum β-Lactamase in the Democratic Republic of the Congo

Clin Infect Dis. 2017 Oct 1;65(7):1229-1231. doi: 10.1093/cid/cix342.

Abstract

We report a typhoid fever case with a Salmonella enterica serovar Typhi isolate showing extended spectrum β-lactamase (ESBL) production in the Democratic Republic of the Congo. Whole genome sequencing revealed that the strain carried a plasmid-mediated CTX-M-15 ESBL gene and did not belong to the dominant H58 Salmonella Typhi clade.

Keywords: Democratic Republic of the Congo; Salmonella Typhi; extended-spectrum beta lactamases (ESBL); typhoid fever.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Democratic Republic of the Congo / epidemiology
  • Genome, Bacterial / genetics
  • Humans
  • Male
  • Phylogeny
  • Salmonella typhi / enzymology*
  • Salmonella typhi / genetics
  • Typhoid Fever / epidemiology
  • Typhoid Fever / microbiology
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • beta-lactamase CTX-M-15
  • beta-Lactamases