A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver

Jordan E Otto; Cigall Kadoch

doi:10.1016/j.ccell.2017.10.014

A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver

Cancer Cell. 2017 Nov 13;32(5):542-543. doi: 10.1016/j.ccell.2017.10.014.

Authors

Jordan E Otto¹, Cigall Kadoch²

Affiliations

¹ Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
² Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA. Electronic address: [email protected].

PMID: 29136498
DOI: 10.1016/j.ccell.2017.10.014

Abstract

In this issue of Cancer Cell, Sun et al. describe context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) complex subunit ARID1A in the development and progression of hepatocellular carcinoma (HCC).

Publication types

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MeSH terms

Animals
Carcinoma, Hepatocellular*
Genes, Tumor Suppressor
Humans
Liver Neoplasms*
Mice
Oncogenes