World's smallest combined en bloc liver-pancreas transplantation

Pediatr Transplant. 2018 Feb;22(1):10.1111/petr.13082. doi: 10.1111/petr.13082. Epub 2017 Nov 15.

Abstract

We present a case of a 2-year-old child who underwent a combined en bloc liver and pancreas transplant following complications of WRS. WRS is characterized clinically through infantile insulin-dependent diabetes mellitus, neutropenia, recurrent infections, propensity for liver failure following viral infections, bone dysplasia, and developmental delay. Usually, death occurs from fulminant liver and concomitant kidney failure. Few cases with WRS are reported in the literature, mostly from consanguineous parents. To the best of our knowledge, combined en bloc liver and pancreas transplant has not been performed in small children.

Keywords: Wolcott-Rallison syndrome; en bloc liver and pancreas transplant.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Diabetes Mellitus, Type 1 / surgery*
  • Epiphyses / abnormalities*
  • Epiphyses / surgery
  • Female
  • Humans
  • Liver Transplantation / methods*
  • Osteochondrodysplasias / surgery*
  • Pancreas Transplantation / methods*

Supplementary concepts

  • Wolcott-Rallison syndrome