Distal Weak Coordination of Acetamides in Ruthenium(II)-Catalyzed C-H Activation Processes

Qingqing Bu; Torben Rogge; Vladislav Kotek; Lutz Ackermann

doi:10.1002/anie.201711108

Distal Weak Coordination of Acetamides in Ruthenium(II)-Catalyzed C-H Activation Processes

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):765-768. doi: 10.1002/anie.201711108. Epub 2017 Dec 12.

Authors

Qingqing Bu¹, Torben Rogge¹, Vladislav Kotek¹, Lutz Ackermann¹

Affiliation

¹ Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.

PMID: 29141119
DOI: 10.1002/anie.201711108

Abstract

C-H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C-H functionalization offers ample scope-including twofold oxidative C-H functionalizations and alkyne hydroarylations-through facile base-assisted internal electrophilic-type substitution (BIES) C-H ruthenation by weak O-coordination.

Keywords: arylacetamides; density functional theory; homogeneous catalysis; mechanisms; ruthenium.

Publication types

Research Support, Non-U.S. Gov't