Gastrointestinal and Hepatic Disease in Vasculitis

Rheum Dis Clin North Am. 2018 Feb;44(1):1-14. doi: 10.1016/j.rdc.2017.09.001.

Abstract

Vasculitis is an inflammatory condition that targets the blood vessels, which may occur in isolation or as a component of a systemic inflammatory condition. Although many of the vasculitides can directly affect the organs of the gastrointestinal system, some types exhibit a proclivity for certain gastrointestinal and hepatic organs. Often a patient presents with nonspecific symptoms, delaying the diagnosis and treatment of the underlying vasculitis. Vasculitis can also present with severe manifestations, such as upper gastrointestinal bleeds and bowel perforation. It is important to identify the signs and symptoms of vasculitis in gastrointestinal system and institute appropriate treatment.

Keywords: Antineutrophil cytoplasmic antibody–associated vasculitis; Esophageal diseases; Gastrointestinal diseases; Granulomatosis with polyangiitis; Kawasaki disease; Mouth diseases; Polyarteritis nodosa; Vasculitis.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic / immunology*
  • Disease Management
  • Gastrointestinal Diseases* / complications
  • Gastrointestinal Diseases* / immunology
  • Humans
  • Inflammation / immunology
  • Liver Diseases* / complications
  • Liver Diseases* / immunology
  • Vasculitis* / complications
  • Vasculitis* / immunology
  • Vasculitis* / therapy

Substances

  • Antibodies, Antineutrophil Cytoplasmic