KIT D816V- chronic myelomonocytic leukemia progressing to KIT D816V+ associated to mast cell leukemia responding to allogeneic hematopoietic cell transplantation

Ann Hematol. 2018 Mar;97(3):533-535. doi: 10.1007/s00277-017-3187-3. Epub 2017 Nov 18.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Allografts
  • Amino Acid Substitution*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Combined Modality Therapy
  • Disease Progression
  • Genetic Association Studies
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunoglobulin kappa-Chains / blood
  • Leukemia, Mast-Cell / drug therapy
  • Leukemia, Mast-Cell / genetics*
  • Leukemia, Mast-Cell / pathology
  • Leukemia, Mast-Cell / therapy
  • Leukemia, Myelomonocytic, Chronic / drug therapy
  • Leukemia, Myelomonocytic, Chronic / genetics*
  • Leukemia, Myelomonocytic, Chronic / pathology
  • Leukemia, Myelomonocytic, Chronic / therapy
  • Male
  • Middle Aged
  • Monoclonal Gammopathy of Undetermined Significance / blood
  • Monoclonal Gammopathy of Undetermined Significance / genetics
  • Mutation, Missense*
  • Neoplasm Proteins / genetics*
  • Neoplasms, Second Primary / drug therapy
  • Neoplasms, Second Primary / genetics*
  • Neoplasms, Second Primary / pathology
  • Neoplasms, Second Primary / therapy
  • Paraproteins / analysis
  • Point Mutation*
  • Proto-Oncogene Proteins c-kit / genetics*
  • Remission Induction

Substances

  • Immunoglobulin kappa-Chains
  • Neoplasm Proteins
  • Paraproteins
  • Proto-Oncogene Proteins c-kit