Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma

Tarig Babiker; Efstathia Kyrodimou; Daniel M Berney; Mark Gurnell; William M Drake; Antonia Brooke

doi:10.1002/ccr3.1148

Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma

Clin Case Rep. 2017 Sep 14;5(11):1768-1771. doi: 10.1002/ccr3.1148. eCollection 2017 Nov.

Authors

Tarig Babiker¹, Efstathia Kyrodimou¹, Daniel M Berney², Mark Gurnell³, William M Drake⁴, Antonia Brooke¹

Affiliations

¹ Departments of Endocrinology and Histopathology Royal Devon and Exeter Hospital Barrack Road Exeter EX2 5DW UK.
² Department of Histopathology Barts Cancer Institute Queen Mary, University of London London EC1A7BE UK.
³ Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science National Institute for Health Research Cambridge Biomedical Research Centre Addenbrooke's Hospital University of Cambridge Cambridge CB2 0QQ UK.
⁴ Department of Endocrinology St Bartholomew's Hospital London EC1A7BE UK.

Abstract

A 60-year-old man with a pre-existing stable sacrococcygeal teratoma developed acromegaly, ectopic Cushing's syndrome, and 5HIAA secretion. To our knowledge, this represents the first reported case of ACTH and serotonin secretion, and likely GHRH or GH cosecretion, from a sacrococcygeal teratoma in an adult.

Keywords: ACTH; Acromegaly; Cushing's; neuroendocrine; teratoma.

Publication types

Case Reports